The lab’s broad research objectives are to understand the brain computations involved in the processing of sensory information. We have a strong interest in understanding visual processing and its contributions to behavior from a retina-centric point of view. In particular, how the information extracted from visual scene by the retina relates to downstream brain computations and behavior. To address these questions we employ electrophysiological and advanced imaging techniques to probe neural activity, molecular techniques to target and manipulate specific cell types and viral tracing techniques to unravel the connectivity between identified neurons. These lines of inquiry address fundamental issues about how information is disseminated in the brain, the collective encoding of information by populations of neurons and the computations performed by identified neural circuits.
- Yonehara K., Farrow K., Ghanem A., Hillier D., Balint K., Teixeira M., Jüttner J., Noda M., Neve R., Conzelmann K., Roska B. 2013. The first stage of cardinal direction selectivity is localized to the dendrites of retinal ganglion cells. Neuron. vol.79 (6) , pp. 1078-1085
- Farrow K., Teixeira M., Szikra T., Viney T., Balint K., Yonehara K., Roska B. 2013. Ambient illumination toggles a neuronal circuit switch in the retina and visual perception at cone threshold. Neuron. vol.78 (2) , pp. 325-338
- Fiscella M., Farrow K., Jones I., Jäckel D., Müller J., Frey U., Bakkum D., Hantz P., Roska B., Hierlemann A. 2012. Recording from defined populations of retinal ganglion cells using a high-density CMOS-integrated microelectrode array with real-time switchable electrode selection. Journal of Neuroscience Methods. vol.211 (1) , pp. 103-113
- Farrow K., Masland R. 2011. Physiological clustering of visual channels in the mouse retina. Journal of Neurophysiology. vol.105 (4) , pp. 1516-1530