The research group ‘Neural Circuit Development and Regeneration’ (NCDR), established in 2007, has a strong interest in defining the molecular mechanisms underlying neural circuit development, as well as neuroinflammation, neuronal survival and regeneration in the injured and diseased central nervous system (CNS). Their research largely focuses on neurodegenerative and inflammatory diseases affecting the visual system and is dedicated to the investigation of the molecular pathways involved in survival and regeneration of retinal ganglion cells (RGCs) and their axons after optic neuropathy in both zebrafish (Danio rerio) and mice (Mus musculus). Over the past months, the research group also initiated research related to aging, in which they specifically address the effect of ‘inflammaging’ on neuronal survival and regeneration. Several mouse and zebrafish models, state-of-the-art molecular, biochemical, morphological, proteomic and optogenetic technologies, behavioral assays and ex vivo and in vitro experiments are being used to define the importance of selected molecules, e.g. proteinases, kinases, growth factors and signaling neuropeptides, and to determine molecular pathways underlying neuroprotection and regeneration in the CNS.
- De Groef L., Van Hove I., Dekeyster E., Stalmans I., Moons L. 2014. MMPs in the neuroretina and optic nerve: modulators of glaucoma pathogenesis and repair?. Investigative Ophthalmology & Visual Science. vol.55 (3) , pp. 1953-1964
- Verslegers M., Van Hove I., Dekeyster E., Gantois I., Hu T., D'Hooge R., Arckens L., Moons L. 2015. MMP-2 mediates Purkinje cell morphogenesis and spine development in the mouse cerebellum. Brain Structure and Function. vol.220 (3) , pp. 1601-1617
- Gaublomme D., Buyens T., De Groef L., Stakenborg M., Janssens E., Ingvarsen S., Porse A., Behrendt N., Moons L. 2014. Matrix metalloproteinase 2 and membrane-type 1 matrix metalloproteinase co-regulate axonal outgrowth of mouse retinal ganglion cells. Journal of Neurochemistry. vol.129 (6) , pp. 966-979
- Verslegers M., Lemmens K., Van Hove I., Moons L. 2013. Matrix metalloproteinase-2 and -9 as promising benefactors in development, plasticity and repair of the nervous system. Progress in Neurobiology. vol. , pp. 60-78
- Janssens E., Gaublomme D., De Groef L., Darras V., Arckens L., Delorme N., Claes F., Van Hove I., Moons L. 2013. Matrix metalloproteinase-14 in the zebrafish: an eye on retinal and retinotectal development. PLoS One. vol.8 (1) , pp. 1-17