Our research presently focuses on two independent problems in insect developmental physiology. At one hand we try to understand the endocrine regulation of protein meal dependent reproduction in the anautogenous fleshly. Fleshflies represent a workable alternative model for blood meal dependent reproduction in mosquitoes. We tackle this problem using a combination of classical physiology with tools from both molecular biology and peptidomics. As a second model, in direct support of the GOA convent HSV, we try to understand innate immunity in locusts in which, in contrast to the situation in most other insects, the defense system mainly depend upon cellular immunity. Indeed the locust seems to minimally invest in the synthesis of antimicrobial peptides. In essence we try to elucidate the cytokine dependent pathways which regulate hemocytes proliferatio. To do so we are developing a locust cell line model starting from hemocyte precursor cells.
- Duressa T., Vanlaer R., Huybrechts R. 2015. Locust cellular defense against infections: Sites of pathogen clearance and hemocyte proliferation. Developmental and Comparative Immunology. vol. , pp. 244-253
- Bil M., Broeckx V., Landuyt B., Huybrechts R. 2014. Differential peptidomics highlights adipokinetic hormone as key player in regulating digestion in anautogenous flesh fly, Sarcophaga crassipalpis. General and Comparative Endocrinology. vol. , pp. 49-56
- Tobback J., Verlinden H., Vuerinckx K., Vleugels R., Vanden Broeck J., Huybrechts R. 2013. Developmental- and food-dependent foraging transcript levels in the desert locust. Insect Science. vol.20 (6) , pp. 679-688
- Verlinden H., Lismont E., Bil M., Urlacher E., Mercer A., Vanden Broeck J., Huybrechts R. 2013. Characterisation of a functional allatotropin receptor in the bumblebee, Bombus terrestris (Hymenoptera, Apidae). General and Comparative Endocrinology. vol. , pp. 193-200
- Tobback J., Vuerinckx K., Boerjan B., Huybrechts R. 2012. RNA interference mortality points to non-circadian functions for the clock gene in the desert locust Schistocerca gregaria. Insect Molecular Biology. vol.21 (3) , pp. 369-381