The research of the Laboratory of Comparative Endocrinology group is focused on the role of hormones in the development and growth of vertebrates. We focus on the thyroid axis but also investigate interactions with hormones of other endocrine axes such as glucocorticoids and sex steroids. Our current research projects can be grouped in three major topics: (1) the role of thyroid hormones in different aspects of embryonic and larval development studied mainly in zebra fish and chicken, (2) the role of thyroid hormone transport and metabolism in brain development studied in chicken embryos and zebra finch hatchlings and (3) the role of thyroid hormones in adult neuroplasticity studied in the visual system of adult zebra fish and the song control system in starling. We also have several national and international collaborations investigating thyroid hormone metabolism and function in other vertebrate models as well as human disease.
- Geysens S., Ferran J., Van Herck S., Tylzanowski P., Puelles L., Darras V. 2012. Dynamic mRNA distribution pattern of thyroid hormone transporters and deiodinases during early embryonic chicken brain development. Neuroscience. vol. , pp. 69-85
- Darras V., Van Herck S. 2012. Iodothyronine deiodinase structure and function: from ascidians to humans. Journal of Endocrinology. vol.215 (2) , pp. 189-206
- Van Herck S., Geysens S., Bald E., Chwatko G., Delezie E., Dianati E., Ahmed R., Darras V. 2013. Maternal transfer of methimazole and effects on thyroid hormone availability in embryonic tissues. Journal of Endocrinology. vol.218 (1) , pp. 105-115
- Heijlen M., Houbrechts A., Bagci E., Van Herck S., Kersseboom S., Esguerra C., Blust R., Visser T., Knapen D., Darras V. 2014. Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish. Endocrinology. vol.155 (4) , pp. 1547-1559
- Bhumika S., Darras V. 2014. Role of thyroid hormones in different aspects of nervous system regeneration in vertebrates. General and Comparative Endocrinology. vol. , pp. 86-94