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Patrick Van Dijck

Patrick Van Dijck
Kasteelpark Arenberg 31 - box 2438
3001 Leuven
Belgium
room: 00.03

tel: +32 16 32 15 12 or +32163 21500
fax: +32163 21979

The first and largest subgroup is focusing on glucose and amino acid sensing and signal transduction pathways in the human fungal pathogens Candida albicans and Candida glabrata. In order to study these pathways we are developing genome-wide Candida specific protein-protein interaction tools, including FRET based biosensors. We have developed an in vivo subcutaneous rodent model system to study biofilms of Candida sp. We use this model to test novel drugs (e.g. essential oil components), to identify genes involved in biofilm formation and to study the host immune response.Finally, we have identified a possible mechanism that allows the appearance of resistance to azole drugs and we are determining the underlying molecular mechanism. The second subgroup is working on plant trehalose metabolism. On the one hand we want to understand the role of trehalose biosynthesis genes in plant development and stress tolerance.  We are using various strategies to use trehalose metabolism in order to generate plants with a better stress tolerance. 

Selected publications