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Plants support life on earth by solar energy-driven photosynthesis, but - as sessile, autotrophic organisms - are constantly challenged by changing environmental conditions. Sugars (and especially glucose and sucrose, the main products of photosynthesis) have been identified as important regulatory molecules, integrating metabolic, developmental and environmental cues. Conversely, the SnRK1 protein kinase (the ortholog of mammalian AMPK) acts as an evolutionarily conserved ‘fuel gauge’, triggering massive reprogramming of transcription in response to diverse stress conditions that affect carbon and energy supplies. Using a combination of molecular, biochemical and genetic approaches, our group aims at elucidating (i) the molecular mechanisms controlling SnRK1 activity in response to metabolic status, (ii) transcriptional and post-transcriptional mechanisms involved in SnRK1-regulation of primary and secondary (flavonoid) metabolism, (iii) the role of metabolic gradients and cell-autonomous SnRK1 signaling in the control of leaf growth and (iv) the role of SnRK1 signaling in plant stress tolerance and defense.
- Rolland F., Baena-Gonzalez E., Sheen J. 2006. Sugar sensing and signaling in plants: conserved and novel mechanisms. Annual review of plant biology. vol. , pp. 675-709
- Baena-González E., Rolland F., Thevelein J., Sheen J. 2007. A central integrator of transcription networks in plant stress and energy signalling. Nature. vol.448 (7156) , pp. 938-42
- Vandesteene L., Ramon M., Le Roy K., Van Dijck P., Rolland F. 2010. A Single Active Trehalose-6-P Synthase (TPS) and a Family of Putative Regulatory TPS-Like Proteins in Arabidopsis. Molecular plant. vol.3 (2) , pp. 406-419
- Ramon M., Ruelens P., Li Y., Sheen J., Geuten K., Rolland F. 2013. The hybrid Four-CBS-Domain KINβγ subunit functions as the canonical γ subunit of the plant energy sensor SnRK1. The Plant Journal. vol.75 (1) , pp. 11-25
- Li Y., Van den Ende W., Rolland F. 2014. Sucrose induction of anthocyanin biosynthesis is mediated by DELLA. Molecular Plant. vol.7 (3) , pp. 570-572