Wim Van den Ende
Our research focuses on soluble sugar metabolism and signaling in plants, especially under stress conditions. The roles of these sugars (hexose, sucrose, fructan, RFOs) and the enzymes involved in their synthesis and degradation are studied, with focus on new concepts such as “sweet immunity”, “fructan/RFO signaling”, “sugars as antioxidants” and “the function of plant defective invertases/FEHs”. Long-term goals include i) the development of high yield, stress tolerant plants ii) the use of natural sweets to prime plants for multi-stress tolerance iii) the development of superior enzymes for industrial applications (e.g. prebiotics for food industries).
- Zhang J., Xu Y., Chen W., Dell B., Vergauwen R., Biddulph B., Khan N., Luo H., Appels R., Van den Ende W. 2015. A wheat 1-FEH w3 variant underlies enzyme activity for stem WSC remobilization to grain under drought. New Phytologist. vol.205 (1) , pp. 293-305
- Peukert M., Thiel J., Peshev D., Weschke W., Van den Ende W., Mock H., Matros A. 2014. Spatio-temporal dynamics of fructan metabolism in developing barley grains. The Plant Cell. vol. , pp. 3728-3744
- Le Roy K., Vergauwen R., Struyf T., Yuan S., Lammens W., Matrai J., De Maeyer M., Van den Ende W. 2013. Understanding the role of defective invertases in plants: tobacco Nin88 fails to degrade sucrose. Plant Physiology. vol.161 (4) , pp. 1670-1681
- Lammens W., Le Roy K., Yuan S., Vergauwen R., Rabijns A., Van Laere A., Strelkov S., Van den Ende W. 2012. Crystal structure of 6-SST/6-SFT from Pachysandra terminalis, a plant fructan biosynthesizing enzyme in complex with its acceptor substrate 6-kestose. The Plant Journal. vol.70 (2) , pp. 205-219
- Hothorn M., Van den Ende W., Lammens W., Rybin V., Scheffzek K. 2010. Structural insights into the pH-controlled targeting of plant cell-wall invertase by a specific inhibitor protein. Proceedings of the National Academy of Sciences of the United States of America. vol.107 (40) , pp. 17427-17432