Publications

Laboratory of Neural Circuit Development and Regeneration - Naamsestraat 61- B-3000 Leuven - Belgium
For a reprint contact the author(s)

2011

  • Van Bergen, T., Van de Veire, S., Vandewalle, E., Dewerchin, M., Stassen, J.-M., Moons, L., Stalmans, I. The role of different VEGF isoforms in scar formation after glaucoma filtration surgery. Experimental Eye Research, submitted.
  • Chaballe, L., Close, P., Sempels, M., Delstanche, S., Fanielle, J., Moons L., Carmeliet, P., Schoenen, J., Chariot, A., Franzen, R. (2011). Involvement of placental growth factor in Wallerian degeneration. GLIA, 59(3), art.nr. 10.1002/glia.21108, 379-396. 

2010

  • Ruiz de Almodovar, C., Coulon, C., Salin, P.A., Knevels, E., Chounlamountri, N., Poesen, K., Hermans, K., Lambrechts, D.,Van Geyte, K., Dhondt, J., Dresselaers, T., Renaud, J., Aragones, J., Zacchigna, S., Geudens, I., Gall, D., Stroobants, S., Mutin, M., Dassonville, K., Storkebaum, E., Jordan, B.F., Eriksson, U., Moons, L., D’Hooge, R., Haigh, J.J., Belin, M.F., Schiffmann, S., Van Hecke, P., Gallez, B., Vinckier, S. CheÅLdotal, A., Honnorat, J., Thomasset, N., Carmeliet, P., Meissirel, C. Matrix‐binding VEGF isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1. Journal of Neuroscience, 30(45), 15052-15066.
  • Roncal, C., Buysschaert, I., Gerdes, N., Georgiadou, M., Ovchinnikova, O., Fischer, C., Stassen, J., Moons, L., Collen, D., De Bock, K., Hansson, G., Carmeliet, P. (2010). Short-term delivery of anti-PlGF antibody delays progression of atherosclerotic plaques to vulnerable lesions. Cardiovascular Research, 86(1):29-36.

2009

  • Koch, M., Dettori, D., Van Nuffelen, A., Souffreau, J., Marconcini, L., Wallays, G., Moons, L., Bruyère, F., Oliviero, S., Noel, A., Foidart, J., Carmeliet, P., Dewerchin, M. (2009). VEGF-D deficiency in mice does not affect embryonic or postnatal lymphangiogenesis but reduces lymphatic metastasis. Journal of Pathology, 219(3), 356-364.
  • Tjwa, M., Moons, L., Lutgens, E. (2009). Pleiotropic role of growth arrest-specific gene 6 in atherosclerosis. Current opinion in lipidology, 20(5), 386-92.
  • Serneels, L.*, Van Biervliet, J.*, Craessaerts, K., Dejaegere, T., Horré, K., Vanhoutvin, T., Esselmann, H., Paul, S., Schäfer, M., Berezovska, O., Hyman, B., Sprangers, B., Sciot, R., Moons, L., Jucker, M., Yang, Z., May, P., Karran, E., Willtfang, J., D’Hooge, R., De Strooper, B. (2009). γ-secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer’s Disease. Science, 324(5927), 639-642.
  • Li, Z., Van Bergen, T., Van de Veire, S., Van de Vel, I., Moreau, H., Dewerchin, M., Maudgal, P., Zeyen, T., Spileers, W., Moons, L., Stalmans, I. (2009). Inhibition of Vascular Endothelial Growth Factor Reduces Scar Formation after Glaucoma Filtration Surgery. Investigative Ophthalmology & Visual Science, 50(11), 5217-5225.
  • Tjwa, M., Sidenius, N., Moura, R., Jansen, A., Theunissen, K., Andolfo, A., De Mol, M., Dewerchin, M., Moons, L., Blasi, F., Verfaillie, C., Carmeliet, P. (2009). Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells. Journal of Clinical Investigation, 119(4), 1008-1018.
  • Vanhaesebrouck, S., Daniels, H., Moons, L., Vanhole, C., Carmeliet, P., de Zegher, F. (2009). Oxygen-Induced Retinopathy in Mice: Amplification by Neonatal IGF-I Deficit and Attenuation by IGF-I Administration. Pediatric research, 65(3), 307-310.
  • Tjwa, M., Moons, L., Verfaillie, C., Carmeliet, P. (2009). Antibiotics may impair hematopoietic recovery after cytotoxic myeloablation. Blood, 113(7), 1608-1609.
  • Coosemans, A., Van Hove, T., Verbist, G., Moons, L., Neven, P., Moerman, P., Vergote, I., Van Gool, S., Amant, F. (2009). Wilms’ tumour gene 1 (WT1) positivity in endothelial cells surrounding epithelial uterine tumours. Histopathology, 54(3), 384-387.
  • Zacchigna, S., Oh, H., Wilsch-Braeuninger, M., Missol-Kolka, E., Jaszai, J., Jansen, A., Tanimoto, N., Tonagel, F., Seeliger, M., Huttner, W., Corbeil, D., Dewerchin, M., Vinckier, S., Moons, L., Carmeliet, P. (2009). Loss of the Cholesterol-Binding Protein Prominin-1/CD133 Causes Disk Dysmorphogenesis and Photoreceptor Degeneration. Journal of Neuroscience, 29(7), 2297-2308.

2008

  • Roncal C, Buysschaert I, Chorianopoulos E, Georgiadou M, Meilhac O, Demol M, Michel JB, Vinckier S, Moons L & P. Carmeliet (2008) Beneficial effects of prolonged systemic administration of PlGF on late outcome of post-ischaemic myocardial performance. J Pathol., 216(2):236-244.
  • Ny A, Koch M, Vandevelde W, Schneider M, Fischer C, Diez-Juan A, Neven E, Sunit M, Van de Velde W, Geudens I, Lambrechts D, Moons L, Plaisance S, Carmeliet P & M. Dewerchin (2008) Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemico-genetic study in Xenopus tadpoles. Blood, 112(5):1740-9.
  • Lutgens, E., Tjwa, M., Garcia de Frutos, P., Wijnands, E., Beckers, L., Dahlbäck, B., Daemen, M., Carmeliet, P., Moons, L. (2008). Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis. Journal of Pathology, 216(1), 55-63.
  • Li X, Tjwa M, Van Hove I, Enholm B, Neven E, Paavonen K, Jeltsch M, Diez-Juan T, Sievers RE, Chorianopoulos E, Wada H, Vanwildemeersch M, Noel A, Foidart JM, Springer ML, von Degenfeld G, Dewerchin M, Blau H, Alitalo K, Eriksson U, Carmeliet P & L. Moons (2008) Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium. Arterioscler Thromb Vasc Biol., 28(9):1614-20.
  • Bruyère F, Melen-Lamalle L, Blacher S, Roland G, Thiry M, Moons L, Frankenne F, Carmeliet P, Alitalo K, Libert C, Sleeman JP, Foidart JM A. Noël (2008) Modeling lymphangiogenesis in a three-dimensional culture system. Nat Methods, 5(5):431-7
  • Tjwa M, Bellido-Martin L, Lin Y, Lutgens E, Garcia de Frutos P, Autiero M, Bono F, Moura R, Billiau A, Levi M, , Aparicio C, Burnier L, Plaisance S, Dewerchin M, Arnout J, Herbert JM, Waer M, García de Frutos P, Dahlbäck B, Carmeliet P, Hoylaerts MF & L. Moons
  • (2008) Gas6 promotes inflammation by orchestrating interactions between endothelial cells, platelets and leukocytes. Blood,111(8):4096-105.
  • Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, Harten SK, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P & P. Carmeliet (2008) Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet., 40(2):170-80.
  • Li L, Lundkvist A, Andersson D, Wilhelmsson U, Nagai N, Pardo AC, Nodin C, Ståhlberg A, Aprico K, Larsson K, Yabe T, Moons L, Fotheringham A, Davies I, Carmeliet P, Schwartz JP, Pekna M, Kubista M, Blomstrand F, Maragakis N, Nilsson M & M. Pekny (2008) Protective role of reactive astrocytes in brain ischemia. J Cereb Blood Flow Metab., 28(3):468-81

2007

  • Cacquevel M, Launay S, Castel H, Benchenane K, Chéenne S, Buée L, Moons L, Delacourte A, Carmeliet P & D. Vivien (2007) Ageing and amyloid-beta peptide deposition contribute to an impaired brain tissue plasminogen activator activity by different mechanisms. Neurobiol Dis., 27(2):164-73.
  • Umans L, Cox L, Tjwa M, Bito V, Vermeire L, Laperre K, Sipido K, Moons L, Huylebroeck D & A. Zwijsen (2007) Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis. Am J Pathol., 170(5):1460-72.
  • Tayade C, Hilchie D, He H, Fang Y, Moons L, Carmeliet P, Foster RA& BA Croy (2007) Genetic deletion of placenta growth factor in mice alters uterine NK cells. J Immunol., 178(7):4267-75.
  • Li L, Lundkvist A, Andersson D, Wilhelmsson U, Nagai N, Pardo AC, Nodin C, Ståhlberg A, Aprico K, Larsson K, Yabe T, Moons L, Fotheringham A, Davies I, Carmeliet P, Schwartz JP, Pekna M, Kubista M, Blomstrand F, Maragakis N, Nilsson M, Pekny M. (2007) Protective role of reactive astrocytes in brain ischemia. J Cereb Blood Flow Metab. Aug 29; 28(3):468-81.
  • Fischer C, Jonckx B, Mazzone M, Zacchigna S, Loges S, Pattarini L, Chorianopoulos E, Liesenborghs L, Koch M, De Mol M, Autiero M, Wyns S, Plaisance S, Moons L, van Rooijen N, Giacca M, Stassen JM, Dewerchin M, Collen D & P. Carmeliet P (2007) Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell, 131(3):463-75.
  • Tirziu D, Chorianopoulos E, Moodie KL, Palac RT, Zhuang ZW, Tjwa M, Roncal C, Eriksson U, Fu Q, Elfenbein A, Hall AE, Carmeliet P, Moons L & M. Simons (2007) Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice. J Clin Invest., 117(11):3188-97.
  • Zwerts F, Lupu F, De Vriese A, Pollefeyt S, Moons L, Altura RA, Jiang Y, Maxwell PH, Hill P, Oh H, Rieker C, Collen D, Conway SJ & EM Conway (2007) Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure. Blood, 109(11):4742-52.

2006

  • Tjwa M, Carmeliet P & L. Moons (2006) Novel transgenic rabbit model sheds light on the puzzling role of matrix metalloproteinase-12 in atherosclerosis. Circulation, 113(16):1929-32.

2005

  • Van Calsteren K, Debiec-Rychter M, Moerman P, Tulunay G, Verbist G, Caluwaerts S, Moons L, Vergote I, Amant F. (2005) Clinicopathologic markers of uterine leiomyosarcoma originating from smooth muscle tumors of low malignancy. Eur Clinics Obstet Gynaecol 2005;1:164-170.
  • Ny A, Koch M, Schneider M, Neven E, Tong RT, Maity S, Fischer C, Plaisance S, Lambrechts D, Heligon C, Terclavers S, Ciesiolka M, Kalin R, Man WY, Senn I, Wyns S, Lupu F, Brandli A, Vleminckx K, Collen D, Dewerchin M, Conway EM, Moons L, Jain RK, Carmeliet P. (2005) A genetic Xenopus laevis tadpole model to study lymphangiogenesis. Nat Med. Sep 2005;11(9):998-1004.
  • Compernolle V, Dewerchin M, Moons L, Carmeliet P. (2005) Vasculaire endotheliale groeifactor en hypoxie-induceerbare factor 2a: drijvende krachten achter longmaturatie; belang voor respiratoir distress syndroom. Tijdschr Kindergeneeskunde. 2005;73:59-64.
  • Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, Dewerchin M, Jain RK, Plate KH, Carmeliet P. (2005) Genetic evidence for a tumor suppressor role of HIF-2alpha. Cancer Cell. Aug 2005;8(2):131-141.
  • Zanetta L, Corada M, Grazia Lampugnani M, Zanetti A, Breviario F, Moons L, Carmeliet P, Pepper MS, Dejana E. (2005) Downregulation of vascular endothelial-cadherin expression is associated with an increase in vascular tumor growth and hemorrhagic complications. Thromb Haemost. Jun 2005;93(6):1041-1046.
  • Storkebaum E, Lambrechts D, Dewerchin M, Moreno-Murciano MP, Appelmans S, Oh H, Van Damme P, Rutten B, Man WY, De Mol M, Wyns S, Manka D, Vermeulen K, Van Den Bosch L, Mertens N, Schmitz C, Robberecht W, Conway EM, Collen D, Moons L, Carmeliet P. (2005) Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nat Neurosci. Jan 2005;8(1):85-92.
  • Moons L, Carmeliet P, Dewerchin M. (2005) Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders. In: Janigro T, ed. Cell Cycle Book. Cleveland: Humana Press; 2005:245-264. ISBN 1-5882-9529-X.
  • Melis E, Moons L, Arnout J, Hoylaerts MF, Collen D, Carmeliet P, Dewerchin M. (2005) Thrombophilia in mice expressing a tissue factor variant lacking its transmembrane and cytosolic domain. Biochem Biophys Res Commun. Jul 29 2005;333(2):488-495.
  • Li X, Tjwa M, Moons L, Fons P, Noel A, Ny A, Zhou JM, Lennartsson J, Li H, Luttun A, Ponten A, Devy L, Bouche A, Oh H, Manderveld A, Blacher S, Communi D, Savi P, Bono F, Dewerchin M, Foidart JM, Autiero M, Herbert JM, Collen D, Heldin CH, Eriksson U, Carmeliet P. (2005) Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors. J Clin Invest. Jan 2005;115(1):118-127.
  • Kryczek I, Lange A, Mottram P, Alvarez X, Cheng P, Hogan M, Moons L, Wei S, Zou L, Machelon V, Emilie D, Terrassa M, Lackner A, Curiel TJ, Carmeliet P, Zou W. (2005) CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers. Cancer Res. Jan 15 2005;65(2):465-472.
  • Khurana R, Moons L, Shafi S, Luttun A, Collen D, Martin JF, Carmeliet P, Zachary IC. (2005) Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation. Circulation. May 31 2005;111(21):2828-2836.
  • Heymans S, Lupu F, Terclavers S, Vanwetswinkel B, Herbert JM, Baker A, Collen D, Carmeliet P, Moons L. (2005) Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice. Am J Pathol. Jan 2005;166(1):15-25.

2004

  • Van Eynde A, Nuytten M, Dewerchin M, Schoonjans L, Keppens S, Beullens M, Moons L, Carmeliet P, Stalmans W, Bollen M. (2004) The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation. Mol Cell Biol. Jul 2004;24(13):5863-5874.
  • Van Den Bosch L, Storkebaum E, Vleminckx V, Moons L, Vanopdenbosch L, Scheveneels W, Carmeliet P, Robberecht W. (2004) Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration. Neurobiol Dis. Oct 2004;17(1):21-28.
  • Luttun A, Lutgens E, Manderveld A, Maris K, Collen D, Carmeliet P, Moons L. (2004) Loss of matrix metalloproteinase-9 or matrix metalloproteinase-12 protects apolipoprotein E-deficient mice against atherosclerotic media destruction but differentially affects plaque growth. Circulation. Mar 23 2004;109(11):1408-1414.
  • Curiel TJ, Cheng P, Mottram P, Alvarez X, Moons L, Evdemon-Hogan M, Wei S, Zou L, Kryczek I, Hoyle G, Lackner A, Carmeliet P, Zou W. (2004) Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer. Cancer Res. Aug 15 2004;64(16):5535-5538.

2003


Stalmans I, Lambrechts D, De Smet F, Jansen S, Wang J, Maity S, Kneer P, von der Ohe M, Swillen A, Maes C, Gewillig M, Molin DG, Hellings P, Boetel T, Haardt M, Compernolle V, Dewerchin M, Plaisance S, Vlietinck R, Emanuel B, Gittenberger-de Groot AC, Scambler P, Morrow B, Driscol DA, Moons L, Esguerra CV, Carmeliet G, Behn-Krappa A, Devriendt K, Collen D, Conway SJ, Carmeliet P. (2003) VEGF: a modifier of the del22q11 (DiGeorge) syndrome? Nat Med. Feb 2003;9(2):173-182.


Moons L, Luttun A, Carmeliet P, Conway EM. (2003) Mouse models to study pro- and anti-angiogenic potential: novel roles for PlGF and Flt1. In: Ince C, ed. ’The Physiological Genomics of the Critically Ill Mouse. Amsterdam: Kluwer Academic Publishers; 2003:329-347. ISBN: 1-4020-7641-X


Moons L, Autiero M, Plaisance S, Conway EM, Carmeliet P, Dewerchin M. (2003) Do we need other targets for treating angiogenic disorders: novel opportunities with Plgf. In: Arnout J, de Gaetano G, Hoylaerts M, et al., eds. Thrombosis. Fundamental and Clinical Aspects. Leuven: University Press; 2003:225-240. ISBN 9-0586-7335-9


Lambrechts D, Storkebaum E, Morimoto M, Del-Favero J, Desmet F, Marklund SL, Wyns S, Thijs V, Andersson J, van Marion I, Al-Chalabi A, Bornes S, Musson R, Hansen V, Beckman L, Adolfsson R, Pall HS, Prats H, Vermeire S, Rutgeerts P, Katayama S, Awata T, Leigh N, Lang-Lazdunski L, Dewerchin M, Shaw C, Moons L, Vlietinck R, Morrison KE, Robberecht W, Van Broeckhoven C, Collen D, Andersen PM, Carmeliet P. (2003) VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat Genet. Aug 2003;34(4):383-394.


Dewerchin M, Herault JP, Wallays G, Petitou M, Schaeffer P, Millet L, Weitz JI, Moons L, Collen D, Carmeliet P, Herbert JM. (2003) Life-threatening thrombosis in mice with targeted Arg48-to-Cys mutation of the heparin-binding domain of antithrombin. Circ Res. Nov 28 2003;93(11):1120-1126.


Autiero M, Waltenberger J, Communi D, Kranz A, Moons L, Lambrechts D, Kroll J, Plaisance S, De Mol M, Bono F, Kliche S, Fellbrich G, Ballmer-Hofer K, Maglione D, Mayr-Beyrle U, Dewerchin M, Dombrowski S, Stanimirovic D, Van Hummelen P, Dehio C, Hicklin DJ, Persico G, Herbert JM, Shibuya M, Collen D, Conway EM, Carmeliet P. (2003) Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nat Med. Jul 2003;9(7):936-943.

2002
VandenDriessche T, Thorrez L, Naldini L, Follenzi A, Moons L, Berneman Z, Collen D, Chuah MK. (2002) Lentiviral vectors containing the human immunodeficiency virus type-1 central polypurine tract can efficiently transduce nondividing hepatocytes and antigen-presenting cells in vivo. Blood. Aug 1 2002;100(3):813-822.


Stalmans I, Ng YS, Rohan R, Fruttiger M, Bouche A, Yuce A, Fujisawa H, Hermans B, Shani M, Jansen S, Hicklin D, Anderson DJ, Gardiner T, Hammes HP, Moons L, Dewerchin M, Collen D, Carmeliet P, D'Amore PA. (2002) Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J Clin Invest. Feb 2002;109(3):327-336.


Mattot V, Moons L, Lupu F, Chernavvsky D, Gomez RA, Collen D, Carmeliet P. (2002) Loss of the VEGF(164) and VEGF(188) isoforms impairs postnatal glomerular angiogenesis and renal arteriogenesis in mice. J Am Soc Nephrol. Jun 2002;13(6):1548-1560.


Luttun A, Tjwa M, Moons L, Wu Y, Angelillo-Scherrer A, Liao F, Nagy JA, Hooper A, Priller J, De Klerck B, Compernolle V, Daci E, Bohlen P, Dewerchin M, Herbert JM, Fava R, Matthys P, Carmeliet G, Collen D, Dvorak HF, Hicklin DJ, Carmeliet P. (2002) Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med. Aug 2002;8(8):831-840.


Luttun A, Lupu F, Storkebaum E, Hoylaerts MF, Moons L, Crawley J, Bono F, Poole AR, Tipping P, Herbert JM, Collen D, Carmeliet P. (2002) Lack of plasminogen activator inhibitor-1 promotes growth and abnormal matrix remodeling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. Mar 1 2002;22(3):499-505.


Luttun A, Brusselmans K, Fukao H, Tjwa M, Ueshima S, Herbert JM, Matsuo O, Collen D, Carmeliet P, Moons L. (2002) Loss of placental growth factor protects mice against vascular permeability in pathological conditions. Biochem Biophys Res Commun. Jul 12 2002;295(2):428-434.


Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, Plaisance S, Dor Y, Keshet E, Lupu F, Nemery B, Dewerchin M, Van Veldhoven P, Plate K, Moons L, Collen D, Carmeliet P. (2002) Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med. Jul 2002;8(7):702-710.

2001
Oosthuyse B, Moons L, Storkebaum E, Beck H, Nuyens D, Brusselmans K, Van Dorpe J, Hellings P, Gorselink M, Heymans S, Theilmeier G, Dewerchin M, Laudenbach V, Vermylen P, Raat H, Acker T, Vleminckx V, Van Den Bosch L, Cashman N, Fujisawa H, Drost MR, Sciot R, Bruyninckx F, Hicklin DJ, Ince C, Gressens P, Lupu F, Plate KH, Robberecht W, Herbert JM, Collen D, Carmeliet P. (2001) Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet. Jun 2001;28(2):131-138.


Nuyens D, Stengl M, Dugarmaa S, Rossenbacker T, Compernolle V, Rudy Y, Smits JF, Flameng W, Clancy CE, Moons L, Vos MA, Dewerchin M, Benndorf K, Collen D, Carmeliet E, Carmeliet P. (2001) Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome. Nat Med. Sep 2001;7(9):1021-1027.


Moons L, Vanlinthout I, Roelants I, Moreadith R, Collen D, Rapold HJ. (2001) Toxicology studies with recombinant staphylokinase and with SY 161-P5, a polyethylene glycol-derivatized cysteine-substitution mutant. Toxicol Pathol. May-Jun 2001;29(3):285-291.


Melis E, Moons L, De Mol M, Herbert JM, Mackman N, Collen D, Carmeliet P, Dewerchin M. (2001) Targeted deletion of the cytosolic domain of tissue factor in mice does not affect development. Biochem Biophys Res Commun. Aug 24 2001;286(3):580-586.


Levi M, Moons L, Bouche A, Shapiro SD, Collen D, Carmeliet P. (2001) Deficiency of urokinase-type plasminogen activator-mediated plasmin generation impairs vascular remodeling during hypoxia-induced pulmonary hypertension in mice. Circulation. Apr 17 2001;103(15):2014-2020.


Carmeliet P, Moons L, Luttun A, Vincenti V, Compernolle V, De Mol M, Wu Y, Bono F, Devy L, Beck H, Scholz D, Acker T, DiPalma T, Dewerchin M, Noel A, Stalmans I, Barra A, Blacher S, Vandendriessche T, Ponten A, Eriksson U, Plate KH, Foidart JM, Schaper W, Charnock-Jones DS, Hicklin DJ, Herbert JM, Collen D, Persico MG. (2001) Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med. May 2001;7(5):575-583.

2000
Dewerchin M, Liang Z, Moons L, Carmeliet P, Castellino FJ, Collen D, Rosen ED. (2000) Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice. Thromb Haemost. Feb 2000;83(2):185-190.


Creemers E, Cleutjens J, Smits J, Heymans S, Moons L, Collen D, Daemen M, Carmeliet P. (2000) Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction. Am J Pathol. Jun 2000;156(6):1865-1873.

1999
Lijnen HR, Lupu F, Moons L, Carmeliet P, Goulding D, Collen D. (1999) Temporal and topographic matrix metalloproteinase expression after vascular injury in mice. Thromb Haemost. May 1999;81(5):799-807.


Heymans S, Luttun A, Nuyens D, Theilmeier G, Creemers E, Moons L, Dyspersin GD, Cleutjens JP, Shipley M, Angellilo A, Levi M, Nube O, Baker A, Keshet E, Lupu F, Herbert JM, Smits JF, Shapiro SD, Baes M, Borgers M, Collen D, Daemen MJ, Carmeliet P. (1999) Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure. Nat Med. Oct 1999;5(10):1135-1142.


Chan JC, Carmeliet P, Moons L, Rosen ED, Huang ZF, Broze GJ, Jr., Collen D, Castellino FJ. (1999) Factor VII deficiency rescues the intrauterine lethality in mice associated with a tissue factor pathway inhibitor deficit. J Clin Invest. Feb 1999;103(4):475-482.


Carmeliet P, Ng YS, Nuyens D, Theilmeier G, Brusselmans K, Cornelissen I, Ehler E, Kakkar VV, Stalmans I, Mattot V, Perriard JC, Dewerchin M, Flameng W, Nagy A, Lupu F, Moons L, Collen D, D'Amore PA, Shima DT. (1999) Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nat Med. May 1999;5(5):495-502.


Carmeliet P, Lampugnani MG, Moons L, Breviario F, Compernolle V, Bono F, Balconi G, Spagnuolo R, Oostuyse B, Dewerchin M, Zanetti A, Angellilo A, Mattot V, Nuyens D, Lutgens E, Clotman F, de Ruiter MC, Gittenberger-de Groot A, Poelmann R, Lupu F, Herbert JM, Collen D, Dejana E. (1999) Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell. Jul 23 1999;98(2):147-157.


Batten TF, Moons L, Vandesande F. (1999) Innervation and control of the adenohypophysis by hypothalamic peptidergic neurons in teleost fishes: EM immunohistochemical evidence. Microsc Res Tech. Jan 1 1999;44(1):19-35.

1998
Moons L, Shi C, Ploplis V, Plow E, Haber E, Collen D, Carmeliet P. (1998) Reduced transplant arteriosclerosis in plasminogen-deficient mice. J Clin Invest. Nov 15 1998;102(10):1788-1797.


Lijnen HR, Van Hoef B, Lupu F, Moons L, Carmeliet P, Collen D. (1998) Function of the plasminogen/plasmin and matrix metalloproteinase systems after vascular injury in mice with targeted inactivation of fibrinolytic system genes. Arterioscler Thromb Vasc Biol. Jul 1998;18(7):1035-1045.


Jalbert LR, Rosen ED, Moons L, Chan JC, Carmeliet P, Collen D, Castellino FJ. (1998) Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice. J Clin Invest. Oct 15 1998;102(8):1481-1488.


Carmeliet P, Moons L, Dewerchin M, Rosenberg S, Herbert JM, Lupu F, Collen D. (1998) Receptor-independent role of urokinase-type plasminogen activator in pericellular plasmin and matrix metalloproteinase proteolysis during vascular wound healing in mice. J Cell Biol. Jan 12 1998;140(1):233-245.


Carmeliet P, Moons L, Collen D. (1998) Mouse models of angiogenesis, arterial stenosis, atherosclerosis and hemostasis. Cardiovasc Res. Jul 1998;39(1):8-33.


Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, Keshert E. (1998) Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. Jul 30 1998;394(6692):485-490.

1997
Rosen ED, Chan JC, Idusogie E, Clotman F, Vlasuk G, Luther T, Jalbert LR, Albrecht S, Zhong L, Lissens A, Schoonjans L, Moons L, Collen D, Castellino FJ, Carmeliet P. (1997) Mice lacking factor VII develop normally but suffer fatal perinatal bleeding. Nature. Nov 20 1997;390(6657):290-294.


Qu Y, Moons L, Vandesande F. (1997) Determination of serotonin, catecholamines and their metabolites by direct injection of supernatants from chicken brain tissue homogenate using liquid chromatography with electrochemical detection. J Chromatogr B Biomed Sci Appl. Dec 19 1997;704(1-2):351-358.


Carmeliet P, Moons L, Stassen JM, De Mol M, Bouche A, van den Oord JJ, Kockx M, Collen D. (1997) Vascular wound healing and neointima formation induced by perivascular electric injury in mice. Am J Pathol. Feb 1997;150(2):761-776.


Carmeliet P, Moons L, Ploplis V, Plow E, Collen D. (1997) Impaired arterial neointima formation in mice with disruption of the plasminogen gene. J Clin Invest. Jan 15 1997;99(2):200-208.


Carmeliet P, Moons L, Lijnen R, Janssens S, Lupu F, Collen D, Gerard RD. (1997) Inhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: a gene targeting and gene transfer study in mice. Circulation. Nov 4 1997;96(9):3180-3191.


Carmeliet P, Moons L, Lijnen R, Baes M, Lemaitre V, Tipping P, Drew A, Eeckhout Y, Shapiro S, Lupu F, Collen D. (1997) Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation. Nat Genet. Dec 1997;17(4):439-444.


Carmeliet P, Moons L, Herbert JM, Crawley J, Lupu F, Lijnen R, Collen D. (1997) Urokinase but not tissue plasminogen activator mediates arterial neointima formation in mice. Circ Res. Nov 1997;81(5):829-839.


Carmeliet P, Moons L, Dewerchin M, Mackman N, Luther T, Breier G, Ploplis V, Muller M, Nagy A, Plow E, Gerard R, Edgington T, Risau W, Collen D. (1997) Insights in vessel development and vascular disorders using targeted inactivation and transfer of vascular endothelial growth factor, the tissue factor receptor, and the plasminogen system. Ann N Y Acad Sci. Apr 15 1997;811:191-206.

1996
Nong Z, Stassen JM, Moons L, Collen D, Janssens S. (1996) Inhibition of tissue angiotensin-converting enzyme with quinapril reduces hypoxic pulmonary hypertension and pulmonary vascular remodeling. Circulation. Oct 15 1996;94(8):1941-1947.


Matsuno H, Stassen JM, Moons L, Vermylen J, Hoylaerts MF. (1996) Neointima formation in injured hamster carotid artery is effectively prevented by the combination G4120 and quinapril. Thromb Haemost. Aug 1996;76(2):263-269.


Lijnen HR, Carmeliet P, Bouche A, Moons L, Ploplis VA, Plow EF, Collen D. (1996) Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen. Blood. Aug 1 1996;88(3):870-876.


Dewerchin M, Nuffelen AV, Wallays G, Bouche A, Moons L, Carmeliet P, Mulligan RC, Collen D. (1996) Generation and characterization of urokinase receptor-deficient mice. J Clin Invest. Feb 1 1996;97(3):870-878.


Carmeliet P, Mackman N, Moons L, Luther T, Gressens P, Van Vlaenderen I, Demunck H, Kasper M, Breier G, Evrard P, Muller M, Risau W, Edgington T, Collen D. (1996) Role of tissue factor in embryonic blood vessel development. Nature. Sep 5 1996;383(6595):73-75.


Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, Nagy A. (1996) Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. Apr 4 1996;380(6573):435-439.

1995
Dhondt E, Moons L, Pijcke K, Vandesande F. (1995) Immunocytochemistry of coexisting LHRH-I, beta-endorphin and vasotocin in the chicken hypothalamus. Archives Néerlandaises de Zoologie, 1995; 45(1-2):22-24.


Ploplis VA, Carmeliet P, Vazirzadeh S, Van Vlaenderen I, Moons L, Plow EF, Collen D. (1995) Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice. Circulation. Nov 1 1995;92(9):2585-2593.


Moons L, D'Hondt E, Pijcke K, Vandesande F. (1995) Noradrenergic system in the chicken brain: immunocytochemical study with antibodies to noradrenaline and dopamine-beta-hydroxylase. J Comp Neurol. Sep 18 1995;360(2):331-348.


Lijnen HR, Moons L, Beelen V, Carmelie P, Collen D. (1995) Biological effects of combined inactivation of plasminogen activator and plasminogen activator inhibitor-1 gene function in mice. Thromb Haemost. Oct 1995;74(4):1126-1131.

1994
Van Gils J, Absil P, Moons L, Grauwels L, Vandesande F, Balthazart J. (1994) Distribution of beta-endorphin-like-immunoreactive structures in the chicken and quail brain as demonstrated with a new homologous antibody directed against a synthetic peptide. J Comp Neurol. Dec 15 1994;350(3):382-396.


Moons L, van Gils J, Ghijsels E, Vandesande F. (1994) Immunocytochemical localization of L-dopa and dopamine in the brain of the chicken (Gallus domesticus). J Comp Neurol. Aug 1 1994;346(1):97-118.

1993
van Gils J, Absil P, Grauwels L, Moons L, Vandesande F, Balthazart J. (1993) Distribution of luteinizing hormone-releasing hormones I and II (LHRH-I and -II) in the quail and chicken brain as demonstrated with antibodies directed against synthetic peptides. J Comp Neurol. Aug 8 1993;334(2):304-323.


Kühn ER, Berghman LR, Moons L, Vandesande F, Decuypere E, Darras V. (1993) Hypothalamic and peripheral control of thyroid function during the life cycle of the chicken. In: Sharp PJ, ed. Avian Endocrinology. Bristol: Ltd; 1993:29-46.


Batten TF, Berry PA, Maqbool A, Moons L, Vandesande F. (1993) Immunolocalization of catecholamine enzymes, serotonin, dopamine and L-dopa in the brain of Dicentrarchus labrax (Teleostei). Brain Res Bull. 1993;31(3-4):233-252.

1992
Moons L, Batten TF, Vandesande F. (1992) Comparative distribution of substance P (SP) and cholecystokinin (CCK) binding sites and immunoreactivity in the brain of the sea bass (Dicentrarchus labrax). Peptides. Jan-Feb 1992;13(1):37-46.

1991
Smets G, Vauquelin G, Moons L, Smitz J, Kloppel G. (1991) Receptors for corticotropin-releasing hormone in human pituitary: binding characteristics and autoradiographic localization to immunocytochemically defined proopiomelanocortin cells. J Clin Endocrinol Metab. Aug 1991;73(2):268-274.


Moons L, Berghman LR, Vandesande F. (1991) Immunoaffinity purification and partial characterization of sea bass (Dicentrarchus labrax) growth hormone. Gen Comp Endocrinol. Aug 1991;83(2):265-275.


Moons L, Batten TF, Vandesande F. (1991) Autoradiographic distribution of galanin binding sites in the brain and pituitary of the sea bass (Dicentrarchus labrax). Neurosci Lett. Feb 11 1991;123(1):49-52.

1990
Batten TF, Cambre ML, Moons L, Vandesande F. (1990) Comparative distribution of neuropeptide-immunoreactive systems in the brain of the green molly, Poecilia latipinna. J Comp Neurol. Dec 22 1990;302(4):893-919.


Batten TF, Moons L, Cambre ML, Vandesande F, Seki T, Suzuki M. (1990) Thyrotropin-releasing hormone-immunoreactive system in the brain and pituitary gland of the sea bass (Dicentrarchus labrax, Teleostei). Gen Comp Endocrinol. Sep 1990;79(3):385-392.


Cambre M, Mareels G, Corneillie S, Moons L, Ollevier F, Vandesande F. (1990) Chronological appearance of the different hypophysial hormones in the pituitary of sea bass larvae (Dicentrarchus labrax) during their early development: an immunocytochemical demonstration. Gen Comp Endocrinol. Mar 1990;77(3):408-415.


Batten TF, Moons L, Cambre M, Vandesande F. (1990) Anatomical distribution of galanin-like immunoreactivity in the brain and pituitary of teleost fishes. Neurosci Lett. Mar 26 1990;111(1-2):12-17.

1989
Moons L, Cambre M, Ollevier F, Vandesande F. (1989) Immunocytochemical demonstration of close relationships between neuropeptidergic nerve fibers and hormone-producing cell types in the adenohypophysis of the sea bass (Dicentrarchus labrax). Gen Comp Endocrinol. Feb 1989;73(2):270-283.


Moons L, Cambre M, Batten TF, Vandesande F. (1989) Autoradiographic localization of binding sites for vasotocin in the brain and pituitary of the sea bass (Dicentrarchus labrax). Neurosci Lett. May 1989;100(1-3):11-16.

1988
Vandesande F, Marivoet S, Moons L, Cambre M, Meeuwis R, Batten T. (1988) Recent immunocytochemical results concerning the hypothalamo-hypophysial axis in vertebrates. Basic Appl Histochem. 1988;32(1):31-42.


Olivereau M, Moons L, Olivereau J, Vandesande F. (1988) Coexistence of corticotropin-releasing factor-like immunoreactivity and vasotocin in perikarya of the preoptic nucleus in the eel. Gen Comp Endocrinol. Apr 1988;70(1):41-48.


Moons L, Cambre M, Marivoet S, Batten TF, Vanderhaeghen JJ, Ollevier F, Vandesande F. (1988) Peptidergic innervation of the adrenocorticotropic hormone (ACTH)- and growth hormone (GH)-producing cells in the pars distalis of the sea bass (Dicentrarchus labrax). Gen Comp Endocrinol. Nov 1988;72(2):171-180.


Marivoet S, Moons L, Vandesande F. (1988) Localization of growth hormone releasing factor-like immunoreactivity in the hypothalamo-hypophyseal system of the frog (Rana temporaria) and the sea bass (Dicentrarchus labrax). Gen Comp Endocrinol. 1988 Oct;72(1):72-9.